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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
12.42
Human Site:
Y214
Identified Species:
19.52
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y214
E
M
E
V
G
T
T
Y
V
T
D
K
S
E
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y214
E
M
E
V
G
T
T
Y
V
T
D
K
S
E
E
Dog
Lupus familis
XP_531814
1283
145094
S197
D
A
K
E
E
G
S
S
D
E
I
S
S
G
V
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y214
E
T
E
V
H
E
A
Y
L
S
D
K
S
E
E
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y217
E
T
Q
V
H
G
A
Y
L
S
D
K
S
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
E318
C
S
E
P
S
D
T
E
E
A
E
E
E
E
M
Frog
Xenopus laevis
NP_001089247
1340
149481
V197
D
S
E
E
D
M
E
V
E
E
N
S
S
A
S
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
E216
K
S
T
V
S
D
A
E
M
S
E
E
E
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
P119
D
C
A
S
D
Y
E
P
D
E
N
E
A
S
D
Honey Bee
Apis mellifera
XP_392346
1120
127429
P49
Q
L
N
K
V
K
T
P
S
K
G
K
E
N
K
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
D115
E
A
D
E
N
A
S
D
C
E
V
V
E
S
P
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
A196
E
E
A
S
E
G
S
A
S
E
E
D
I
T
I
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
W204
D
D
S
S
D
E
D
W
G
K
N
A
E
K
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
K197
R
G
A
S
A
L
R
K
V
V
T
D
S
D
D
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D171
V
D
S
E
S
D
E
D
E
Y
L
P
D
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
60
53.3
N.A.
N.A.
20
13.3
6.6
N.A.
0
13.3
6.6
6.6
P-Site Similarity:
100
N.A.
100
26.6
N.A.
73.3
73.3
N.A.
N.A.
33.3
26.6
46.6
N.A.
33.3
33.3
20
20
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
20
0
7
7
20
7
0
7
0
7
7
7
0
% A
% Cys:
7
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
27
14
7
0
20
20
7
14
14
0
27
14
7
7
20
% D
% Glu:
40
7
34
27
14
14
20
14
20
34
20
20
34
34
27
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
14
20
0
0
7
0
7
0
0
7
0
% G
% His:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
7
% I
% Lys:
7
0
7
7
0
7
0
7
0
14
0
34
0
14
14
% K
% Leu:
0
7
0
0
0
7
0
0
14
0
7
0
0
0
0
% L
% Met:
0
14
0
0
0
7
0
0
7
0
0
0
0
0
7
% M
% Asn:
0
0
7
0
7
0
0
0
0
0
20
0
0
7
7
% N
% Pro:
0
0
0
7
0
0
0
14
0
0
0
7
0
0
7
% P
% Gln:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
0
20
14
27
20
0
20
7
14
20
0
14
47
14
7
% S
% Thr:
0
14
7
0
0
14
27
0
0
14
7
0
0
7
0
% T
% Val:
7
0
0
34
7
0
0
7
20
7
7
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
27
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _